The chemicals in magic mushroom that produce the high are called psilocybin and psilocin (and some trace similar compounds). When you eat magic mushrooms, psilocybin is converted into a chemical called psilocin. Psilocin is then absorbed into the blood stream where it is taken to the brain. Source
Psilocin has a chemical structure very similar to the naturally occurring neurotransmitter serotonin. Neurotransmitters are chemicals that cells in the brain (neurons) use to communicate with each other. Varying levels of serotonin will affect sleep, appetite, sensory perception, temperature regulation, pain suppression and mood.
Serotonin is taken up or absorbed by neurons at receptor sites known as the 5-HT receptors. Because psilocin’s chemical structure is very similar to serotonin, it is taken up by the 5-HT2 receptor site (one of several 5-HT receptor types) as are many other common hallucinogens including LSD and mescaline.
After the psilocin molecules bind with the 5-HT2 receptor sites, little is known about what happens. Psilo(cybin)cin is considered a serotonin agonist and possibly may have reuptake inhibitory effects also (SSRI) .There is still not enough data to explain clinically exactly the effect of the active ingredients in psychedelic fungi. What we do know is that psilocin is NOT physically harmful to the body or brain. Psychological conditions can rarely arise from a very profound experience, but no physical harm is done by psilocin even in higher dosages.
In short: psilocin molecules from the mushrooms bind with serotonin receptor sites in the brain and cause the mind to do strange things and scientists aren’t quite sure why.
Psilocybe it’s chemical name is 4-phosphoryloxy-NN-dimethyltryptamine. The Molecular formula is C12H17N204P
Psilocin it’s chemical name is 4-hydroxy-NN-dimethyltryptamine (4-OH-DMT). The Molecular formula: C12H16N20
Psilocybin differs from psilocin in having a phosphate group attached to the molecule at the oxygen atom. In the human body the Psilocybin is transformed into psilocin.
That’s how shrooms work !
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